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Sagar, B. K.
- Sulfisoxazole Guanidinyl Derivatives:Synthesis, Characterization and Docking Studies for potential Anti-TB agents
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1 Department of Chemistry, Bangurnagar Arts, Science and Commerce College, Dandeli- 581325, Karnataka, IN
2 Department of Chemistry, JSS College for Women, Saraswathipuram, Mysore-570 009 Karnataka, IN
3 DOS in Chemistry, University of Mysore, Manasagangothri, Mysore-570 006, Karnataka, IN
1 Department of Chemistry, Bangurnagar Arts, Science and Commerce College, Dandeli- 581325, Karnataka, IN
2 Department of Chemistry, JSS College for Women, Saraswathipuram, Mysore-570 009 Karnataka, IN
3 DOS in Chemistry, University of Mysore, Manasagangothri, Mysore-570 006, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1726-1730Abstract
Guanidine’s are major functionality in natural and synthetic compound, which exhibit a variety of activities like antidiabetic, antimicrobial, antiviral, anticancer, antibiotic and anti-inflammatory etc. The wide spread of guanidine compounds in the field of pharmaceutical, makes them as one of the attractive pharmacophores. The presence of the -CN3 group in guanidine compounds makes them to have efficient affinity towards various substituents with wide range of biochemical activities. In the present study, novel Sulfisoxazole guanidinyl derivatives were synthesized and characterized by LCMS and NMR spectral studies. The synthesized compounds were screened for anti-TB and anti-oxidant activities. It was found that compounds with electron donating groups exhibited superior activity.Keywords
Guanidines, Sulfisoxazole, Anti-TB Activity, Anti-Oxidant Activity.
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